If you want to educate yourself about the pharmaceutical industry (and we all should), I highly recommend this book. The first section of the book is all about recent advancements in biotechnology and offers a (somewhat jaded) view on what the author thinks about big medicine.
Personally, I thought it was amazing because it talked about how the first enzyme replacements were produced. In particular, it talks about a doctor at NIH that harvested the enzyme replacement for Gaucher disease from human placentas. He and his team liquefied placentas for 3 years in order to produce enough enzyme for a small number of infusions (like 4-5). The infusions were given to a very sick 4 yr old child. Up until that experiment, nothing had been shown to work, with just these few infusions, this sick child became temporarily well again. All to vividly, I can imagine how heartbroken the parents felt when the enzyme ran out and they figured out it would take three years to build enough production capacity to produce a steady enough stream of enzyme to actually do a clinical trial.
Reading this book, I realized how far this industry has come. It may a bit academic or too close to home for some people. If you read it (or have read it) let me know.